Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study.

ABSTRACT:

Background

Since influenza often presents non-specifically in infancy, we aimed to assess the extent to which existing respiratory surveillance platforms might underestimate the frequency of severe influenza disease among infants.

Methods

The Influenza and Respiratory Syncytial Virus in Infants (IRIS) study was a prospective observational study done at four hospitals in Albania, Jordan, Nicaragua, and the Philippines. We included acutely ill infants aged younger than 1 year admitted to hospital within 10 days or less of illness onset during two influenza seasons (2015-16 and 2016-17) in Albania, Jordan, and Nicaragua, and over a continuous 34 week period (2015-16) in the Philippines. We assessed the frequency of influenza virus infections by real-time RT-PCR (rRT-PCR) and se

SUBMITTER: Thompson MG 

PROVIDER: S-EPMC7029431 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature