Comprehensive pharmacogenomic characterization of gastric cancer.

ABSTRACT:

Background

Gastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, the clinical translation of molecular-guided targeted therapy is hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating the development of effective treatments.

Methods

To address such challenges, we established a comprehensive dataset of molecularly annotated patient derivatives coupled with pharmacological profiles for 60 targeted agents to explore dynamic pharmacogenomic interactions in gastric cancers.

Results

We identified lineage-specific drug sensitivities based on histopathological and molecular

SUBMITTER: Sa JK 

PROVIDER: S-EPMC7029441 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature