Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer.

ABSTRACT:

Background

Metabolic reprogramming, immune evasion and tumor-promoting inflammation are three hallmarks of cancer that provide new perspectives for understanding the biology of cancer. We aimed to figure out the relationship of tumor glycolysis and immune/inflammation function in the context of breast cancer, which is significant for deeper understanding of the biology, treatment and prognosis of breast cancer.

Methods

Using mRNA transcriptome data, tumor-infiltrating lymphocytes (TILs) maps based on digitized H&E-stained images and clinical information of breast cancer from The Cancer Genome Atlas projects (TCGA), we explored the expression and prognostic implications of glycolysis-related genes, as well as the enrichment scores and dual role of different immune/inflammatio

SUBMITTER: Li W 

PROVIDER: S-EPMC7029444 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature