BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data.

ABSTRACT: The development of large-scale data sets requires a new means to display and disseminate research studies to large audiences. Knowledge of protein-protein interaction (PPI) networks has become a principle interest of many groups within the field of proteomics. At the confluence of technologies, such as cross-linking mass spectrometry, yeast two-hybrid, protein cofractionation, and affinity purification mass spectrometry (AP-MS), detection of PPIs can uncover novel biological inferences at a high-throughput. Thus new platforms to provide community access to large data sets are necessary. To this end, we have developed a web application that enables exploration and dissemination of the growing BioPlex interaction network. BioPlex is a large-scale interactome data set based on AP-MS of baits

SUBMITTER: Schweppe DK 

PROVIDER: S-EPMC7029486 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature