Exploring and analysing single cell multi-omics data with VDJView.

ABSTRACT:

Background

Single cell RNA sequencing provides unprecedented opportunity to simultaneously explore the transcriptomic and immune receptor diversity of T and B cells. However, there are limited tools available that simultaneously analyse large multi-omics datasets integrated with metadata such as patient and clinical information.

Results

We developed VDJView, which permits the simultaneous or independent analysis and visualisation of gene expression, immune receptors, and clinical metadata of both T and B cells. This tool is implemented as an easy-to-use R shiny web-application, which integrates numerous gene expression and TCR analysis tools, and accepts data from plate-based sorted or high-throughput single cell platforms. We utilised VDJView to analyse several 10X scRNA-se

SUBMITTER: Samir J 

PROVIDER: S-EPMC7029546 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature