Defining persistent critical illness based on growth trajectories in patients with sepsis.

ABSTRACT: BACKGROUND:Persistent critical illness is common in critically ill patients and is associated with vast medical resource use and poor clinical outcomes. This study aimed to define when patients with sepsis would be stabilized and transitioned to persistent critical illness, and whether such transition time varies between latent classes of patients. METHODS:This was a retrospective cohort study involving sepsis patients in the eICU Collaborative Research Database. Persistent critical illness was defined at the time when acute physiological characteristics were no longer more predictive of in-hospital mortality (i.e., vital status at hospital discharge) than antecedent characteristics. Latent growth mixture modeling was used to identify distinct trajectory classes by using Sequential Organ F

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7029548 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature