IPCO: Inference of Pathways from Co-variance analysis.

ABSTRACT: BACKGROUND:Key aspects of microbiome research are the accurate identification of taxa and the profiling of their functionality. Amplicon profiling based on the 16S ribosomal DNA sequence is a ubiquitous technique to identify and profile the abundance of the various taxa. However, it does not provide information on their encoded functionality. Predictive tools that can accurately extrapolate the functional information of a microbiome based on taxonomic profile composition are essential. At present, the applicability of these tools is limited due to requirement of reference genomes from known species. We present IPCO (Inference of Pathways from Co-variance analysis), a new method of inferring functionality for 16S-based microbiome profiles independent of reference genomes. IPCO utilises the

SUBMITTER: Das M 

PROVIDER: S-EPMC7029613 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature