Identification of Immune Responses to Japanese Encephalitis Virus Specific T Cell Epitopes.

ABSTRACT: Background: Due to the similarity between the dengue (DENV) and the Japanese encephalitis virus (JEV) there is potential for immune cross-reaction. We sought to identify T cell epitopes that are specific to JEV and do not cross react with DENV. Methodology: 20mer peptides were synthesized from regions which showed >90% conservation. Using IFNγ cultured ELISpot assays, we investigated JEV-specific T cell responses in DENV^- and JEV^- non-immune individuals (DENV^-JEV^- = 21), JEV seronegative and had not received the JE vaccine, but who were DENV seropositive (DENV⁺JEV^- = 22), JEV⁺(seropositive for JEV and had received the JE vaccine), but seronegative for DENV (DENV^-JEV⁺ = 23). We f

SUBMITTER: Pushpakumara PD 

PROVIDER: S-EPMC7029616 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature