Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics.

ABSTRACT: Despite huge need in the medical domain and significant development efforts, artificial cells to date have limited composition and functionality. Although some artificial cells have proven successful for producing therapeutics or performing in vitro specific reactions, they have not been investigated in vivo to determine whether they preserve their architecture and functionality while avoiding toxicity. Here, these limitations are overcome and customizable cell mimic is achieved-molecular factories (MFs)-by supplementing giant plasma membrane vesicles derived from donor cells with nanometer-sized artificial organelles (AOs). MFs inherit the donor cell's natural cytoplasm and membrane, while the AOs house reactive components and provide cell-like architecture and functionality. It is demons

SUBMITTER: Einfalt T 

PROVIDER: S-EPMC7029636 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature