Multiscale Structure-Function Gradients in the Neonatal Connectome.

ABSTRACT: The adult functional connectome is well characterized by a macroscale spatial gradient of connectivity traversing from unimodal toward higher-order transmodal cortices that recapitulates known principles of hierarchical organization and myelination patterns. Despite an emerging literature assessing connectome properties in neonates, the presence of connectome gradients and particularly their correspondence to microstructure remains largely unknown. We derived connectome gradients using unsupervised techniques applied to functional connectivity data from 40 term-born neonates. A series of cortex-wide analysis examined associations to magnetic resonance imaging-derived morphological parameters (cortical thickness, sulcal depth, curvature), measures of tissue microstructure (intracortical T1w

SUBMITTER: Lariviere S 

PROVIDER: S-EPMC7029695 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature