Correlates of Cognitive Function in Sickle Cell Disease: A Meta-Analysis.

ABSTRACT:

Objective

To provide a comprehensive quantitative review of biological, environmental, and behavioral correlates across domains of cognitive function in sickle cell disease (SCD).

Methods

Forty-seven studies were identified in PubMed, MedLine, and PsycINFO involving 2573 participants with SCD.

Results

Meta-analytic findings across all identified samples indicate that hemoglobin and hematocrit were positively correlated with Full Scale IQ [FSIQ; r = .15, 95% confidence interval (CI) = .10 to .21], language and verbal reasoning (r = .18, 95% CI = .11 to .24), and executive function (r = .10, 95% CI = .01 to .19) with small effects and significant heterogeneity. Transcranial Doppler velocity was negatively associated with visual spatial and perceptual reasoning (r = -.18

SUBMITTER: Prussien KV 

PROVIDER: S-EPMC7029698 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature