Gastric Damage and Cancer-Associated Biomarkers in Helicobacter pylori-Infected Children.

ABSTRACT: Helicobacter pylori (H. pylori) is well-known to be involved in gastric carcinogenesis, associated with deregulation of cell proliferation and epigenetic changes in cancer-related genes. H. pylori infection is largely acquired during childhood, persisting long-term in about half of infected individuals, a subset of whom will go on to develop peptic ulcer disease and eventually gastric cancer, however, the sequence of events leading to disease is not completely understood. Knowledge on carcinogenesis and gastric damage-related biomarkers is abundant in adult populations, but scarce in children. We performed an extensive literature review focusing on gastric cancer related biomarkers identified in adult populations, which have been detected in children infected with H. pylori. Biomarkers wer

SUBMITTER: George S 

PROVIDER: S-EPMC7029740 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature