Functional connectivity and structural analysis of trial spinal cord stimulation responders in failed back surgery syndrome.

ABSTRACT: BACKGROUND:Chronic pain has been associated with alterations in brain structure and function that appear dependent on pain phenotype. Functional connectivity (FC) data on chronic back pain (CBP) is limited and based on heterogeneous pain populations. We hypothesize that failed back surgery syndrome (FBSS) patients being considered for spinal cord stimulation (SCS) therapy have altered resting state (RS) FC cross-network patterns that 1) specifically involve emotion and reward/aversion functions and 2) are related to pain scores. METHODS:RS functional MRI (fMRI) scans were obtained for 10 FBSS patients who are being considered for but who have not yet undergone implantation of a permanent SCS device and 12 healthy age-matched controls. Seven RS networks were analyzed including the striatum

SUBMITTER: Pahapill PA 

PROVIDER: S-EPMC7029839 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature