ALK inhibitors for non-small cell lung cancer: A systematic review and network meta-analysis.

ABSTRACT:

Background

We sought to assess the relative effects of individual anaplastic lymphoma kinase (ALK) inhibitors for the treatment of non-small cell lung cancer (NSCLC).

Methods

We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (July 23, 2019) for randomized controlled trials (RCTs) that included participants with ALK- or ROS1-positive NSCLC who received any ALK inhibitor compared with placebo, another ALK inhibitor, or the same ALK inhibitor at a different dose. The primary outcome was treatment-related death. Secondary outcomes were overall survival (OS), progression-free survival (PFS), and serious adverse events. Data were pooled via meta-analysis and network meta-analysis, and risk of bias was assessed. PROSPERO: CRD42017077046.

Results

Thirteen RCT

SUBMITTER: Elliott J 

PROVIDER: S-EPMC7029857 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature