The hourglass organization of the Caenorhabditis elegans connectome.

ABSTRACT: We approach the C. elegans connectome as an information processing network that receives input from about 90 sensory neurons, processes that information through a highly recurrent network of about 80 interneurons, and it produces a coordinated output from about 120 motor neurons that control the nematode's muscles. We focus on the feedforward flow of information from sensory neurons to motor neurons, and apply a recently developed network analysis framework referred to as the "hourglass effect". The analysis reveals that this feedforward flow traverses a small core ("hourglass waist") that consists of 10-15 interneurons. These are mostly the same interneurons that were previously shown (using a different analytical approach) to constitute the "rich-club" of the C. elegans connectome. This

SUBMITTER: Sabrin KM 

PROVIDER: S-EPMC7029875 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature