The cell uptake properties and hyperthermia performance of Zn_0.5Fe_2.5O₄/SiO₂ nanoparticles as magnetic hyperthermia agents.

ABSTRACT: Zn_0.5Fe_2.5O₄ nanoparticles (NPs) of 22 nm are synthesized by a one-pot approach and coated with silica for magnetic hyperthermia agents. The NPs exhibit superparamagnetic characteristics, high-specific absorption rate (SAR) (1083 wg^-1, f = 430 kHz, H = 27 kAm^-1), large saturation magnetization (M _s = 85 emu g^-1), excellent colloidal stability and low cytotoxicity. The cell uptake properties have been investigated by Prussian blue staining, transmission electron microscopy and the inductively coupled plasma-mass spectrometer, which resulted in time-dependent and concentration-dependent internalization. The internalization appeared between 0.5 and 2 h, the NPs were mainly located in the lysosome

SUBMITTER: Wang R 

PROVIDER: S-EPMC7029910 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature