Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination.

ABSTRACT: Influenza is a highly contagious viral pathogen with more than 200,000 cases reported in the United States during the 2017-2018 season. Annual vaccination is recommended by the World Health Organization, with the goal to reduce influenza severity and transmission. Currently available vaccines are about 60% effective, and vaccine effectiveness varies from season to season, as well as between different influenza subtypes within a single season. Immunological imprinting from early-life influenza infection can prominently shape the immune response to subsequent infections. Here, the impact of preexisting B cell memory in the response to quadrivalent influenza vaccine was assessed using blood samples collected from healthy subjects (18-85 years old) prior to and 21-28 days following influenza v

SUBMITTER: Abreu RB 

PROVIDER: S-EPMC7030826 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature