Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner.

ABSTRACT: Colitis, an inflammatory bowel disease, is caused by a variety of factors, but luminal microbiota are thought to play crucial roles in disease development and progression. Indole is produced by gut microbiota and is believed to protect the colon from inflammatory damage. In the current study, we investigated whether indole-3-carbinol (I3C), a naturally occurring plant product found in numerous cruciferous vegetables, can prevent colitis-associated microbial dysbiosis and attempted to identify the mechanisms. Treatment with I3C led to repressed colonic inflammation and prevention of microbial dysbiosis caused by colitis, increasing a subset of gram-positive bacteria known to produce butyrate. I3C was shown to increase production of butyrate, and when mice with colitis were treated with buty

SUBMITTER: Busbee PB 

PROVIDER: S-EPMC7030851 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature