Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.

ABSTRACT: Recently introduced stationary dedicated cardiac SPECT scanners provide new opportunities to quantify myocardial blood flow (MBF) using dynamic SPECT. However, comparing to PET, the low sensitivity of SPECT scanners affects MBF quantification due to the high noise level, especially for ²⁰¹ Thallium (²⁰¹Tl) due to its typically low injected dose. The conventional indirect method for generating parametric images typically starts by reconstructing a time series of frame images followed by fitting the time-activity curve (TAC) for each voxel or segment with an appropriate kinetic model. The indirect method is simple and easy to implement; however, it usually suffers from substantial image noise that could also lead to bias. In this paper, we developed a list mode direct p

SUBMITTER: Shi L 

PROVIDER: S-EPMC7030971 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature