The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease.

ABSTRACT:

Background & aims

Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp. in the fecal mycobiome, yet little is known about the effect of intestinal Candida on the disease. Herein, we evaluated the contributions of Candida albicans and its exotoxin candidalysin in alcohol-associated liver disease.

Methods

C. albicans and the extent of cell elongation 1 (ECE1) were analyzed in fecal samples from controls, patients with alcohol use disorder and those with alcoholic hepatitis. Mice colonized with different and genetically manipul

SUBMITTER: Chu H 

PROVIDER: S-EPMC7031049 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature