Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs.

ABSTRACT: Influence of an intracranial aneurysm (IA) rupture on the expression of miRNAs and the potential significance of the resulting changes remains poorly understood. We aimed to characterize the response to the IA rupture through the analysis of miRNAs in peripheral blood cells. Expression of small RNAs was investigated using deep transcriptome sequencing in patients in the acute phase of an IA rupture (first 72 h), in the chronic phase (3-15 months), and controls. A functional analysis and the potential interactions between miRNAs and target genes were investigated. We also measured the levels of proteins that were influenced by regulated miRNAs. We found that 106 mature miRNAs and 90 miRNA precursors were differentially expressed among the groups. The regulated miRNAs were involved in a vari

SUBMITTER: Korostynski M 

PROVIDER: S-EPMC7031224 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature