A CMOS MEMS-based Membrane-Bridge Nanomechanical Sensor for Small Molecule Detection.

ABSTRACT: Small molecule compounds are necessary to detect with high sensitivity since they may cause a strong effect on the human body even in small concentrations. But existing methods used to evaluate small molecules in blood are inconvenient, costly, time-consuming, and do not allow for portable usage. In response to these shortcomings, we introduce a complementary metal-oxide-semiconductor bio-microelectromechanical system (CMOS BioMEMS) based piezoresistive membrane-bridge (MB) sensor for detecting small molecule (phenytoin) concentrations as the demonstration. Phenytoin is one of anticonvulsant drugs licensed for the management of seizures, which has a narrow therapeutic window hence a level of concentration monitoring was needed. The MB sensor was designed to enhance the structural stability

SUBMITTER: Yen YK 

PROVIDER: S-EPMC7031247 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature