Transdiagnostic Phenotyping Reveals a Host of Metacognitive Deficits Implicated in Compulsivity.

ABSTRACT: Recent work suggests that obsessive-compulsive disorder (OCD) patients have a breakdown in the relationship between explicit beliefs (i.e. confidence about states) and updates to behaviour. The precise computations underlying this disconnection are unclear because case-control and transdiagnostic studies yield conflicting results. Here, a large online population sample (N = 437) completed a predictive inference task previously studied in the context of OCD. We tested if confidence, and its relationship to action and environmental evidence, were specifically associated with self-reported OCD symptoms or common to an array of psychiatric phenomena. We then investigated if a transdiagnostic approach would reveal a stronger and more specific match between metacognitive deficits and clinical ph

SUBMITTER: Seow TXF 

PROVIDER: S-EPMC7031252 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature