Genome-wide DNA methylation meta-analysis in the brains of suicide completers.

ABSTRACT: Suicide is the second leading cause of death globally among young people representing a significant global health burden. Although the molecular correlates of suicide remains poorly understood, it has been hypothesised that epigenomic processes may play a role. The objective of this study was to identify suicide-associated DNA methylation changes in the human brain by utilising previously published and unpublished methylomic datasets. We analysed prefrontal cortex (PFC, n = 211) and cerebellum (CER, n = 114) DNA methylation profiles from suicide completers and non-psychiatric, sudden-death controls, meta-analysing data from independent cohorts for each brain region separately. We report evidence for altered DNA methylation at several genetic loci in suicide cases compared to controls in bo

SUBMITTER: Policicchio S 

PROVIDER: S-EPMC7031296 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature