Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types.

ABSTRACT: Background: Understanding how tumors subvert immune destruction is essential to the development of cancer immunotherapies. New evidence suggests that tumors limit anti-tumor immunity by exploiting transcriptional programs that regulate intratumoral trafficking and accumulation of effector cells. Here, we investigated the gene expression profiles that distinguish immunologically "cold" and "hot" tumors across diverse tumor types. Methods: RNAseq profiles of tumors (n = 8,920) representing 23 solid tumor types were analyzed using immune gene signatures that quantify CD8+ T cell abundance. Genes and pathways associated with a low CD8+ T cell infiltration profile (CD8-Low) were identified by correlation, differential expression, and statistical ranking methods. Gene subset

SUBMITTER: Routh ED 

PROVIDER: S-EPMC7031496 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature