Novel salivary gland allergens from tropical mosquito species and IgE reactivity in allergic patients.

ABSTRACT:

Background

Mosquito allergy is common in tropical countries but remains under-diagnosed. This may be due to the lack of knowledge and diagnostic tools for tropical mosquito allergens.

Objective

We aimed to characterize allergens from tropical mosquito species and investigate IgE reactivity in mosquito-allergic patients to the salivary gland proteins from these mosquitoes.

Methods

Salivary gland extract (SGE) from 4 mosquito species, highly distributed in the tropics, including Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Anopheles dirus b, were studied. SGE-specific IgE and IgG ELISA were developed, and serum from 64 mosquito-allergic and 22 non-allergic healthy control subjects was assayed. Further investigations using IgE-immunoblots fo

SUBMITTER: Opasawatchai A 

PROVIDER: S-EPMC7031643 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature