Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring.

ABSTRACT: Fetal programming has been proposed as a key mechanism underlying the association between intrauterine exposure to maternal diabetes and negative health outcomes in offspring. To determine whether gestational diabetes mellitus (GDM) might leave an imprint in fetal precursors of the amniotic membrane and whether it might be related to adverse outcomes in offspring, a prospective case-control study was conducted, in which amniotic mesenchymal stem cells (AMSCs) and resident macrophages were isolated from pregnant patients, with either GDM or normal glucose tolerance, scheduled for cesarean section. After characterization, functional characteristics of AMSCs were analyzed and correlated with anthropometrical and clinical variables from both mother and offspring. GDM-derived AMSCs displayed an

SUBMITTER: Algaba-Chueca F 

PROVIDER: S-EPMC7031647 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature