Adult tissue-derived neural crest-like stem cells: Sources, regulatory networks, and translational potential.

ABSTRACT: Neural crest (NC) cells are a multipotent stem cell population that give rise to a diverse array of cell types in the body, including peripheral neurons, Schwann cells (SC), craniofacial cartilage and bone, smooth muscle cells, and melanocytes. NC formation and differentiation into specific lineages takes place in response to a set of highly regulated signaling and transcriptional events within the neural plate border. Premigratory NC cells initially are contained within the dorsal neural tube from which they subsequently emigrate, migrating to often distant sites in the periphery. Following their migration and differentiation, some NC-like cells persist in adult tissues in a nascent multipotent state, making them potential candidates for autologous cell therapy. This review discusses the

SUBMITTER: Mehrotra P 

PROVIDER: S-EPMC7031649 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature