A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.

ABSTRACT: Polymorphisms in the human circadian clock gene PERIOD3 (PER3) are associated with a wide variety of phenotypes such as diurnal preference, delayed sleep phase disorder, sleep homeostasis, cognitive performance, bipolar disorder, type 2 diabetes, cardiac regulation, cancer, light sensitivity, hormone and cytokine secretion, and addiction. However, the molecular mechanisms underlying these phenotypic associations remain unknown. Per3 knockout mice (Per3^-/- ) have phenotypes related to activity, sleep homeostasis, anhedonia, metabolism, and behavioral responses to light. Using a protocol that induces behavioral differences in response to light in wild type and Per3^-/- mice, we compared genome-wide expression in the eye and hypothalamus

SUBMITTER: Van der Veen DR 

PROVIDER: S-EPMC7031657 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature