Disentangling non-specific and specific transgenerational immune priming components in host-parasite interactions.

ABSTRACT: Exposure to a pathogen primes many organisms to respond faster or more efficiently to subsequent exposures. Such priming can be non-specific or specific, and has been found to extend across generations. Disentangling and quantifying specific and non-specific effects is essential for understanding the genetic epidemiology of a system. By combining a large infection experiment and mathematical modelling, we disentangle different transgenerational effects in the crustacean model Daphnia magna exposed to different strains of the bacterial parasite Pasteuria ramosa. In the experiment, we exposed hosts to a high dose of one of three parasite strains, and subsequently challenged their offspring with multiple doses of the same (homologous) or a different (heterologous) strain. We find that exposur

SUBMITTER: Ben-Ami F 

PROVIDER: S-EPMC7031663 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature