Effect of Osmolytes on Conformational Behavior of Intrinsically Disordered Protein α-Synuclein.

ABSTRACT: α-Synuclein is an intrinsically disordered protein whose function in a healthy brain is poorly understood. It is genetically and neuropathologically linked to Parkinson's disease (PD). PD is manifested after the accumulation of plaques of α-synuclein aggregates in the brain cells. Aggregates of α-synuclein are very toxic and lead to the disruption of cellular homeostasis and neuronal death. α-Synuclein can also contribute to disease propagation as it may exert noxious effects on neighboring cells. Understanding the mechanism of α-synuclein aggregation will facilitate the problem of dealing with neurodegenerative diseases in general and that of PD in particular. Here, we have used molecular dynamics simulations to investigate the behavior of α-synuclein at various temperatures and in differ

SUBMITTER: Jahan I 

PROVIDER: S-EPMC7031737 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature