Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins.

ABSTRACT: Genipin, a natural compound from Gardenia jasminoides, is a well-known compound in Chinese medicine that is used for the treatment of cancer, inflammation, and diabetes. The use of genipin in classical medicine is hindered because of its unknown molecular mechanisms of action apart from its strong cross-linking ability. Genipin is increasingly applied as a specific inhibitor of proton transport mediated by mitochondrial uncoupling protein 2 (UCP2). However, its specificity for UCP2 is questionable, and the underlying mechanism behind its action is unknown. Here, we investigated the effect of genipin in different systems, including neuroblastoma cells, isolated mitochondria, isolated mitochondrial proteins, and planar lipid bilayer membranes reconstituted with recombinant proteins. We revea

SUBMITTER: Kreiter J 

PROVIDER: S-EPMC7031773 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature