Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations.

ABSTRACT:

Motivation

Breast cancer consists of multiple distinct tumor subtypes, and results from epigenetic and genetic aberrations that give rise to distinct transcriptional profiles. Despite previous efforts to understand transcriptional deregulation through transcription factor networks, the transcriptional mechanisms leading to subtypes of the disease remain poorly understood.

Results

We used a sophisticated computational search of thousands of expression datasets to define extended signatures of distinct breast cancer subtypes. Using ENCODE ChIP-seq data of surrogate cell lines and motif analysis we observed that these subtypes are determined by a distinct repertoire of lineage-specific transcription factors. Furthermore, specific pattern and abundance of copy number and DNA met

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC7031777 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature