Topology-based classification of tetrads and quadruplex structures.

ABSTRACT:

Motivation

Quadruplexes attract the attention of researchers from many fields of bio-science. Due to a specific structure, these tertiary motifs are involved in various biological processes. They are also promising therapeutic targets in many strategies of drug development, including anticancer and neurological disease treatment. The uniqueness and diversity of their forms cause that quadruplexes show great potential in novel biological applications. The existing approaches for quadruplex analysis are based on sequence or 3D structure features and address canonical motifs only.

Results

In our study, we analyzed tetrads and quadruplexes contained in nucleic acid molecules deposited in Protein Data Bank. Focusing on their secondary structure topology, we adjusted its graphical

SUBMITTER: Popenda M 

PROVIDER: S-EPMC7031778 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature