Immune checkpoint inhibitor-induced inflammatory arthritis persists after immunotherapy cessation.

ABSTRACT:

Objective

We sought to investigate the long-term outcomes of patients who develop immune checkpoint inhibitor (ICI)-induced inflammatory arthritis (IA), to define factors associated with IA persistence after ICI cessation, the need for immunosuppressants and the impact of these medications on underlying malignancies.

Methods

We conducted a prospective observational study of patients referred for IA associated with ICIs. Patients were recruited from June 2015 to December 2018. Information was obtained at the baseline visit, and follow-up visits occurred at varying intervals for up to 24 months from ICI cessation. Kaplan-Meier curves were developed to characterise IA persistence. Cox proportional hazards models were used to assess the influence of various factors on IA persist

SUBMITTER: Braaten TJ 

PROVIDER: S-EPMC7031780 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature