White matter lesion location correlates with disability in relapsing multiple sclerosis.

ABSTRACT:

Background

Lesion location is a prognostic factor of disease progression and disability accrual.

Objective

To investigate lesion formation in 11 brain regions, assess correlation between lesion location and physical and cognitive disability measures and investigate treatment effects by region.

Methods

In 2355 relapsing-remitting multiple sclerosis patients from the FREEDOMS and FREEDOMS II studies, we extracted T2-weighted lesion number, volume and density for each brain region; we investigated the (Spearman) correlation in lesion formation between brain regions, studied association between location and disability (at baseline and change over 2 years) using linear/logistic regression and assessed the regional effects of fingolimod versus placebo in negative binomial m

SUBMITTER: Gaetano L 

PROVIDER: S-EPMC7031799 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature