Long-term trends in myocardial sympathetic innervation and function in synucleinopathies.

ABSTRACT:

Introduction

Parkinson disease (PD), pure autonomic failure (PAF), and multiple system atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein and are termed synucleinopathies. Lewy body synucleinopathies involve decreased cardiac sympathetic innervation and functional abnormalities in residual noradrenergic terminals. This observational, retrospective, cohort study describes long-term trends in indices of cardiac sympathetic innervation and function in synucleinopathies.

Methods

Patients with PD (N = 31), PAF (N = 9), or MSA (N = 9) underwent repeated ¹⁸F-dopamine positron emission tomography (median follow-up 3.5 years). Interventricular septal ¹⁸F-dopamine-derived radioactivity 8 min after tracer injection (8' Radi

SUBMITTER: Lamotte G 

PROVIDER: S-EPMC7031858 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature