C-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.

ABSTRACT:

Background

CD8⁺ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system autoimmune disease pathology. We recently identified a novel population of highly cytotoxic c-Met-expressing CD8⁺ T lymphocytes and found that hepatocyte growth factor (HGF) limits effective murine cytotoxic T cell responses in cancer models. Here, we examined the role of c-Met-expressing CD8⁺ T cells by using a MOG_35-55 T cell-mediated EAE model.

Methods

Mice were subcutaneously immunized with myelin oligodendrocyte glycoprotein peptide (MOG)_35-55 in complete Freund's adjuvant (CFA). Peripheral and CNS

SUBMITTER: Benkhoucha M 

PROVIDER: S-EPMC7031922 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature