A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons.

ABSTRACT:

Background

Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized by psychosis as well as multifactorial medical co-morbidities, including metabolic disease, contributing to markedly increased morbidity and mortality. Paradoxically, however, the genetic risk sequences of psychosis and traits associated with metabolic disease, such as body mass, show very limited overlap.

Methods

We investigated the genomic interaction of SCZ with medical conditions and traits, including body mass index (BMI), by exploring the MDN's "spatial genome," including chro

SUBMITTER: Espeso-Gil S 

PROVIDER: S-EPMC7031924 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature