Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.

ABSTRACT: Epidemiological sequencing studies have revealed that somatic mutations characteristic of myeloid neoplasms can be detected in the blood of asymptomatic individuals decades prior to presentation of any clinical symptoms. This premalignant condition is known as clonal hematopoiesis of indeterminate potential (CHIP). Despite the fact these mutant clones become readily detectable in the blood of elderly individuals (∼10% of people over the age of 65), the overall rate of disease progression remains relatively low. Thus, in addition to genetic mutations, there are likely environmental factors that contribute to clonal evolution in people with CHIP. One environmental stress that increases with age is inflammation. Although chronic inflammation is detrimental to the long-term function of normal

SUBMITTER: Zhang CRC 

PROVIDER: S-EPMC7031927 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature