Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.

ABSTRACT:

Background

Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of soft-tissue sarcoma, derived from a peripheral branch or the sheath of the sciatic nerve, brachial plexus, or sacral plexus. The clinical outcomes for MPNST patients with unresectable or metastatic tumors are dismal, and novel therapeutic strategies are required. Although patient-derived cancer cell lines are vital for basic research and preclinical studies, few MPNST cell lines are available from public cell banks. Therefore, the aim of this study was to establish cancer cell lines derived from MPNST patients.

Methods

We used tumor tissues from five patients with MPNSTs, including one derived from a rare bone tissue MPNST. The tumor tissues were obtained at the time of surgery and were immedi

SUBMITTER: Oyama R 

PROVIDER: S-EPMC7031935 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature