Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.

ABSTRACT:

Background

Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal programming may alter the fetal epigenome increasing the risk of metabolic disease in their offspring. The aims of this study were to determine if maternal obesity or diabetes mellitus during pregnancy results in a change in infant methylation of CpG islands adjacent to targeted genes specific for obesity or diabetes disease pathways in a largely Hispanic population.

Methods

Methylation levels in the cord blood of 69 newborns were determined using the Illumina Infi

SUBMITTER: Rizzo HE 

PROVIDER: S-EPMC7031937 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature