Model evaluation for the prediction of solubility of active pharmaceutical ingredients (APIs) to guide solid-liquid separator design.

ABSTRACT: The assumptions and models for solubility modelling or prediction in systems using non-polar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Furthermore, the assumptions concerning heat capacity effects (negligibility, experimental values or approximations) are explored, using non-polar solvents (benzene), or water as reference solvents, for systems with solute melting points in the range of 306-528 K and molecular weights in the range of 90-442 g/mol. New empirical estimation methods for the ΔfusCpi of APIs are presented which correlate the solute molecular masses and van der Waals surface areas with ΔfusCpi . Separate empirical parameters were required for oxygenated and non-oxygenated solutes. Subsequently, the predic

SUBMITTER: Moodley K 

PROVIDER: S-EPMC7032238 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature