SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness.

ABSTRACT: Metastasis is the leading cause of breast cancer-related death and poses a substantial clinical burden owing to a paucity of targeted treatment options. The clinical manifestations of metastasis occur years-to-decades after initial diagnosis and treatment because disseminated tumor cells readily evade detection and resist therapy, ultimately giving rise to recurrent disease. Using an unbiased genetic screen, we identified SLX4-interacting protein (SLX4IP) as a regulator of metastatic recurrence and established its relationship in governing telomere maintenance mechanisms (TMMs). Inactivation of SLX4IP suppressed alternative lengthening of telomeres (ALT), coinciding with activation of telomerase. Importantly, TMM selection dramatically influenced metastatic progression and survival of pati

SUBMITTER: Robinson NJ 

PROVIDER: S-EPMC7032570 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature