Positron Emission Tomography/Computed Tomography with Gallium-68-labeled Prostate-specific Membrane Antigen Detects Relapse After Vascular-targeted Photodynamic Therapy in a Prostate Cancer Model.

ABSTRACT:

Background

Evaluating the efficacy of focal therapy for prostate cancer is limited by current approaches and may be improved with biological imaging techniques.

Objective

We assessed whether positron emission tomography/computed tomography with gallium-68-labeled prostate-specific membrane antigen (⁶⁸Ga-PSMA PET/CT) can be used to predict relapse after vascular-targeted photodynamic therapy (VTP).

Design, setting, and participants

A total of 1×10⁶ LNCaP cells were grafted subcutaneously in the flanks of 6-8-wk-old SCID mice. Of 24 mice with measurable tumors 6 wk after tumor implantation, 20 were treated with VTP (150mW/cm²) to ablate the tumors. Blood prostate-specific antigen (PSA) levels were assessed, and ⁶⁸Ga-PSMA PET/CT images we

SUBMITTER: Alvim R 

PROVIDER: S-EPMC7032651 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature