Scores for sepsis detection and risk stratification - construction of a novel score using a statistical approach and validation of RETTS.

ABSTRACT: BACKGROUND:To allow early identification of patients at risk of sepsis in the emergency department (ED), a variety of risk stratification scores and/or triage systems are used. The first aim of this study was to develop a risk stratification score for sepsis based upon vital signs and biomarkers using a statistical approach. Second, we aimed to validate the Rapid Emergency Triage and Treatment System (RETTS) for sepsis. RETTS combines vital signs with symptoms for risk stratification. METHODS:We retrospectively analysed data from two prospective, observational, multicentre cohorts of patients from studies of biomarkers in ED. A candidate risk stratification score called Sepsis Heparin-binding protein-based Early Warning Score (SHEWS) was constructed using the Least Absolute Shrinkage and S

SUBMITTER: Mellhammar L 

PROVIDER: S-EPMC7032705 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature