Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review.

ABSTRACT: AIMS.:For the past quarter of a century, Frank et al.'s (1991) consensus-based definitions of major depressive disorder (MDD) episode, remission, recovery, relapse and recurrence have been the paramount driving forces for consistency in MDD research as well as in clinical practice. This study aims to review the evidence for the empirical validation of Frank et al.'s proposed concept definitions and to discuss evidence-based modifications. METHODS.:A literature search of Web of Science and PubMed from 1/1/1991 to 08/30/2017 identified all publications which referenced Frank et al.'s request for definition validation. Publications with data relevant for validation were included and checked for referencing other studies providing such data. RESULTS.:A total of 56 studies involving 39 315 subj

SUBMITTER: de Zwart PL 

PROVIDER: S-EPMC7032752 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature