Sex Differences in the Amygdala Resting-State Connectome of Children With Autism Spectrum Disorder.

ABSTRACT:

Background

Multifactorial liability models predict greater dissimilarity in the neural phenotype of autism spectrum disorder (ASD) in female individuals than in male individuals, while gender incoherence and extreme male brain models predict attenuated sex differences in ASD. The amygdala is an informative target to explore these models because it is implicated in both the neurobiology of ASD and sex differences in typical development.

Methods

This study investigated amygdala resting-state functional connectivity in a cohort of 116 children with ASD (36 female) and 58 typically developing children (27 female) 2 to 7 years of age during natural sleep. First, multivariate distance matrix regression assessed global sex and diagnostic differences across the amygdala connectome.

SUBMITTER: Lee JK 

PROVIDER: S-EPMC7033019 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature