BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.

ABSTRACT: BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate cancer cell lines demonstrated that transient overexpression of BRF1 increased cell proliferation whereas the transient downregulation of BRF1 reduced proliferation and mediated cell cycle arrest. Consistent with our clinical observations, BRF1 overexpression in a Pten-deficient mouse (Pten^Δ/Δ BRF1^Tg) prostate cancer model accelerated prostate carcinogenesis and shortened survival. In Pten^Δ/Δ BRF1^Tg tumours, immune and inflammatory processes were altered, with reduced tumoral infiltration of neutrophi

SUBMITTER: Loveridge CJ 

PROVIDER: S-EPMC7033044 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature