Evaluation of the total distribution volume of ¹⁸F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling.

ABSTRACT:

Objective

Boron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[¹⁸F]-fluoro-L-phenylalanine (¹⁸F-FBPA) PET has been employed to estimate ¹⁰B accumulation in target tumors and normal tissues if ¹⁰B borono-L-phenylalanine (¹⁰B-BPA) is used as a boron carrier. The purpose of the current study was to evaluate the total distribution volume (Vt) of ¹⁸F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of ¹⁰B-BPA using obtained Vt values.

Methods

Six healthy volunteers were injected with ¹⁸F-FBPA (3-5 MBq/kg), and 7 PET-CT scans were perf

SUBMITTER: Romanov V 

PROVIDER: S-EPMC7033086 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature